She is most famous for her film "Mermaid". Writing for Hollywood Reporter, Anna Melikyan notes of life "full of mystical coincidences":
"I was born in Armenia, in Yerevan, and moved to Moscow right after graduating from school. My way to filmmaking was a logical step -- actually I did it all my life, although I didn't know that it was directing. I made some shows at school even when I was in a kindergarten. We had a special part of class time that we called "Fairy Tales From Anna." All the children would sit in the circle and I was in the center of it, telling fairy tales. Now I'm doing the same thing, I'm telling fairy tales.
"Mermaid" is a very personal film. I can't say that it's absolutely autobiographical, it wouldn't be true, but it's still much related to me. The themes in "Mermaid" -- wish fulfillment, destiny, accidents and mystical happiness in our everyday life -- all of them are interesting for me. This is probably because these things actually happen. For example, I was in the Taj Mahal hotel in Mumbai (I was presenting "Mermaid" at the festival there), and I decided to change my plane tickets and come back home earlier. I just arrived in Moscow, and I turned on the TV and saw the terrible images of the hotel on fire, and how it was taken by terrorists. If I didn't change my tickets, I would have been there. Life is full of mystical coincidences."
*photo: "Mermaid" - A young woman lives in a world of her own making after she decides to stop speaking in this bittersweet, whimsical tale from writer-director Anna Melikyan. (source)